Hybrid coaxial electrospun nanofibrous scaffolds with limited immunological response created for tissue engineering

Jessica M. Gluck, Paymon Rahgozar, Nilesh P. Ingle, Fironia Rofail, Asdghig Petrosian, Michael G. Cline, Maria C. Jordan, Kenneth P. Roos, William Robb MacLellan, Richard J. Shemin, Sepideh Heydarkhan-Hagvall

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Electrospinning using synthetic and natural polymers is a promising technique for the fabrication of scaffolds for tissue engineering. Numerous synthetic polymers are available to maximize durability and mechanical properties (polyurethane) versus degradability and cell adhesion (polycaprolactone). In this study, we explored the feasibility of creating scaffolds made of bicomponent nanofibers from both polymers using a coaxial electrospinning system. We used a core of poly(urethane) and a sheath of a mixture of poly(ε-caprolactone) and gelatin, all dissolved in 1,1,1,3,3,3-hexafluror-2-propanol. These nanofibrous scaffolds were then evaluated to confirm their core-sheath nature and characterize their morphology and mechanical properties under static and dynamic conditions. Furthermore, the antigenicity of the scaffolds was studied to confirm that there is no significant foreign body response to the scaffold itself that would preclude its use in vivo. The results show the advantages of combining both natural and synethic polymers to create a coaxial scaffold capable of withstanding dynamic culture conditions and encourage cellular migration to the interior of the scaffold for tissue-engineering applications. Also, the results show that there is no significant immunoreactivity in vivo to the components of the scaffolds.

Original languageEnglish (US)
Pages (from-to)180-190
Number of pages11
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume99 B
Issue number1
StatePublished - Oct 2011


  • coaxial
  • electrospinning
  • gelatin
  • polycaprolactone
  • polyurethane
  • tissue engineering


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