Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer

P. P. Provenzano, S. R. Hingorani

Research output: Contribution to journalReview article

124 Citations (Scopus)

Abstract

Pancreatic ductal adenocarcinomas (PDAs) are notoriously aggressive and resistant to treatment. They distinguish themselves further by their robust fibroinflammatory, or desmoplastic, stromal reaction and degree of hypovascularity. Recent findings have revealed multiple mechanisms of stromal complicity in disease pathogenesis and resistance. In this review, we focus on altered physicomechanics as one mechanism of what we term as 'stromal resistance' in PDA. Extremely high interstitial fluid pressures and a dense extracellular matrix combine to limit the delivery and distribution of therapeutic agents. We discuss the genesis and consequences of altered fluid dynamics in PDA and strategies to restore them.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalBritish Journal of Cancer
Volume108
Issue number1
DOIs
StatePublished - Jan 15 2013

Fingerprint

Hyaluronic Acid
Pancreatic Neoplasms
Adenocarcinoma
Pressure
Complicity
Disease Resistance
Extracellular Fluid
Hydrodynamics
Extracellular Matrix
Therapeutics

Keywords

  • Pancreatic ductal adenocarcinoma
  • desmoplasia
  • hyaluronic acid
  • hyaluronidase
  • interstitial fluid pressure
  • stromal resistance

Cite this

Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. / Provenzano, P. P.; Hingorani, S. R.

In: British Journal of Cancer, Vol. 108, No. 1, 15.01.2013, p. 1-8.

Research output: Contribution to journalReview article

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