Hyalinizing cholecystitis with features of immunoglobulin G4-related disease - Coincidence or an unrecognized association? A case report

Rajib K. Gupta, Kurt T. Patton

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Summary Hyalinizing cholecystitis (HC) is a recently described rare subtype of chronic cholecystitis characterized by dense, paucicellular collagenous transmural fibrosis, which usually replaces the mucosa and muscularis propria. Immunoglobulin (Ig)G4-associated cholecystitis is also a newly described cholecystitis variant characterized by transmural or extramural lymphoplasmacytic inflammation, lymphoid follicles, storiform fibrosis, phlebitis, and increased tissue IgG4-positive plasma cells. We describe a case of cholecystitis in an elderly white man who harbored features of both HC and IgG4-associated cholecystitis. In retrospect, the patient also had a significantly elevated serum IgG4 level. To the best of our knowledge, an association between HC and IgG4-related disease has not been previously described in the literature. Although not entirely conclusive, our observations raise the possibility that some cases of HC represent the end stage of IgG4-related disease.

Original languageEnglish (US)
Pages (from-to)625-628
Number of pages4
JournalHuman pathology
Volume46
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • Hyalinizing cholecystitis
  • IgG4-associated cholecystitis
  • IgG4-positive plasma cells
  • IgG4-related disease
  • Porcelain gallbladder

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