Hyaline-Vascular Type Castleman’s Disease, Sarcoidosis, and Crohns Disease

Arjun Gupta, Balaji Ayyar, Hamid Zia, Weina Chen, Samar Harris, Harris V. Naina

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Sarcoidosis and Crohns disease have been associated with increased long term risk of lymphoproliferative disorders, including lymphomas. Newly developed lymphadenopathy in a patient with these disorders should prompt pathological evaluation. Castleman’s disease is a lymphoproliferative disorder characterized by enlarged hyperplastic lymph nodes with regressed follicles surrounded by expanded mantle zones of small lymphocytes, and interfollicular vascular proliferation in the hyaline-vascular type. Similar to sarcoidosis and Crohns disease, its etiology is incompletely understood, although immune dysregulation, genetic factors and infectious and environmental factors are thought to play a role in all three diseases. Interleukin-6 is a possible pathological common factor between these three disease processed. Unicentric, hyaline-vascular type Castleman’s disease can be treated successfully with complete surgical resection. We report a patient with long history of sarcoidosis and Crohns disease with newly developed lymphadenopathy which was found to be due to Castleman’s disease.

Original languageEnglish (US)
Pages (from-to)335-339
Number of pages5
JournalIndian Journal of Hematology and Blood Transfusion
StatePublished - Jun 1 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015, Indian Society of Haematology & Transfusion Medicine.


  • Castleman’s disease
  • Crohns disease
  • Sarcoidosis
  • Surgical resection


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