Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study

Christopher F. McNicoll, Jeanne C. Latourelle, Marcy E. MacDonald, Mark F. Lew, Oksana Suchowersky, Christine Klein, Lawrence I. Golbe, Margery H. Mark, John H. Growdon, G. Frederick Wooten, Ray L. Watts, Mark Guttman, Brad A. Racette, Joel S. Perlmutter, Anwar Ahmed, Holly A. Shill, Carlos Singer, Marie H. Saint-Hilaire, Tiffany Massood, Karen W. HuskeyAnita L. DeStefano, Tammy Gillis, Jayalakshmi Mysore, Stefano Goldwurm, Gianni Pezzoli, Kenneth B. Baker, Ilia Itin, Irene Litvan, Garth Nicholson, Alastair Corbett, Martha Nance, Edward Drasby, Stuart Isaacson, David J. Burn, Patrick F. Chinnery, Peter P. Pramstaller, Jomana Al-Hinti, Anette T. Moller, Karen Ostergaard, Scott J. Sherman, Richard Roxburgh, Barry Snow, John T. Slevin, Franca Cambi, James F. Gusella, Richard H. Myers

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with known onset ages from 248 families, were genotyped for the HD CAG repeat. Genotyping failed in 11 cases leaving 484 for analysis, including 35 LRRK2 carriers. All cases had HD CAG repeats (range, 15-34) below the clinical range for HD, although 5.2% of the sample (n = 25) had repeats in the intermediate range (the intermediate range lower limit = 27; upper limit = 35 repeats), suggesting that the prevalence of intermediate allele carriers in the general population is significant. No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD.

Original languageEnglish (US)
Pages (from-to)1596-1601
Number of pages6
JournalMovement Disorders
Volume23
Issue number11
DOIs
StatePublished - Aug 15 2008

Keywords

  • CAG repeat
  • Genetics
  • Huntington's disease
  • Mitochondria
  • Onset age
  • Parkinson's disease

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    McNicoll, C. F., Latourelle, J. C., MacDonald, M. E., Lew, M. F., Suchowersky, O., Klein, C., Golbe, L. I., Mark, M. H., Growdon, J. H., Wooten, G. F., Watts, R. L., Guttman, M., Racette, B. A., Perlmutter, J. S., Ahmed, A., Shill, H. A., Singer, C., Saint-Hilaire, M. H., Massood, T., ... Myers, R. H. (2008). Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study. Movement Disorders, 23(11), 1596-1601. https://doi.org/10.1002/mds.22186