Humoral immunity in experimental immune carditis

Inderjit S. Anand, N. K. Ganguly, A. K. Khanna, R. N. Chakravarti, P. L. Wahi

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3 Scopus citations

Abstract

An experimental model of carditis has been produced in the rhesus monkey by giving 12 weekly injections of a streptococcal membrane antigen. There was histological evidence of focal myocarditis, subendocardial infiltration with lymphomononuclear cells and in one animal myocardial granuloma formation. No valvular lesions were seen. Humoral immune responses monitored throughout the experiment showed that anti-heart antibodies appeared in circulation after the 2nd injection, attained maximal titres by the 6th injection, and thereafter the titres declined. The anti-membrane antibodies appeared slightly later and these titres kept rising till sacrifice. By the 6th injection there was evidence of complement consumption and appearance of circulating immune complexes. It is concluded that these immunological responses might have a role to play in the pathogenesis of carditis.

Original languageEnglish (US)
Pages (from-to)291-299
Number of pages9
JournalPathology
Volume16
Issue number3
DOIs
StatePublished - 1984

Keywords

  • Anti-heart antibodies
  • Anti-membrane antibodies
  • Circulating immune complexes
  • Complement
  • Experimental immune carditis
  • Rheumatic fever
  • Streptococci

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    Anand, I. S., Ganguly, N. K., Khanna, A. K., Chakravarti, R. N., & Wahi, P. L. (1984). Humoral immunity in experimental immune carditis. Pathology, 16(3), 291-299. https://doi.org/10.3109/00313028409068540