Humoral immune responses to chicken infectious anemia virus in three strains of chickens in a closed flock

Carol Cardona, B. Lucio, P. O'Connell, Jara Jagne, K. A. Schat

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38 Scopus citations

Abstract

This is a comparative study on seroconversion to chicken infectious anemia virus (CIAV) in a closed flock of specific-pathogen-free chickens undergoing a natural outbreak and after vaccination of some of these flocks with a commercial, live vaccine. The N2a strain (B21B21 haplotype) had the highest seroconversion after natural infection (94%) or vaccination (100%), followed by the P2a strain (B19B19) at 75%-82% seroconversion after natural infection and 85% seroconversion after vaccination. The S13 (B13B13) chickens were 26% seropositive after natural infection and 75% seropositive after vaccination. N2a chickens with polymerase chain reaction (PCR)-positive tissues were 97% seropositive compared to 80%-83% PCR-positive and seropositive for the P2a chickens and only 8% seropositive and PCR-positive for the S13 chickens. Seroconversion occurred at or near sexual maturity after natural infection in seven flocks studied.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalAvian Diseases
Volume44
Issue number3
StatePublished - Oct 2 2000

Keywords

  • Chicken infectious anemia virus
  • Circovirus
  • Humoral immunity
  • Immune genetics

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