Human Submandibular Saliva Aggregates HIV

D. Malamud, C. Davis, P. Berthold, E. Roth, H. Friedman

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Incubation of HIV with human whole, parotid, or submandibular saliva leads to a decrease in viral infectivity in Sup-T1 cells. The effect is most pronounced with submandibular saliva. Inhibition is seen within 2 min, and increases with time. There is little inhibition seen after incubation of saliva with HSV, and no effect with adenovirus, suggested that there is some viral specificity. Electron microscopic studies revealed that HIV-saliva aggregates are trapped in 0.45-μm pore size nitrocellulose filters. If these inhibitory effects are manifest in vivo, this could account for the low level of virus detected in oral secretions.

Original languageEnglish (US)
Pages (from-to)633-637
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume9
Issue number7
DOIs
StatePublished - Jul 1993

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    Malamud, D., Davis, C., Berthold, P., Roth, E., & Friedman, H. (1993). Human Submandibular Saliva Aggregates HIV. AIDS Research and Human Retroviruses, 9(7), 633-637. https://doi.org/10.1089/aid.1993.9.633