Human-Phosphate-Binding-Protein inhibits HIV-1 gene transcription and replication

Thomas Cherrier, Mikael Elias, Alicia Jeudy, Guillaume Gotthard, Valentin Le Douce, Houda Hallay, Patrick Masson, Andrea Janossy, Ermanno Candolfi, Olivier Rohr, Eric Chabrière, Christian Schwartz

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Abstract. The Human Phosphate-Binding protein (HPBP) is a serendipitously discovered lipoprotein that binds phosphate with high affinity. HPBP belongs to the DING protein family, involved in various biological processes like cell cycle regulation. We report that HPBP inhibits HIV-1 gene transcription and replication in T cell line, primary peripherical blood lymphocytes and primary macrophages. We show that HPBP is efficient in nave and HIV-1 AZT-resistant strains. Our results revealed HPBP as a new and potent anti HIV molecule that inhibits transcription of the virus, which has not yet been targeted by HAART and therefore opens new strategies in the treatment of HIV infection.

Original languageEnglish (US)
Article number352
JournalVirology journal
Volume8
DOIs
StatePublished - 2011

Keywords

  • HAART
  • HIV-1
  • HPBP
  • transcription

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