Human parvovirus B19 infection leads to downregulation of thyroid, estrogen, and retinoid hormone receptor expression

Igor V. Ignatovich, Jacqueline A. Hobbs

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Erythrovirus B19 (B19V) is a member of the family Parvoviridae. Infection with B19V has been linked to a variety of diseases including erythroid, thyroid, neurological and autoimmune diseases. Here we show that infection of primary CD36+ cells with B19V coincides with downregulation of thyroid, retinoid, and estrogen hormone receptors. In addition we show changes in expression of a variety of related downstream signaling genes participating in cancer and cardiac-related diseases in B19V-infected erythroid primary cells.

Original languageEnglish (US)
Pages (from-to)173-179
Number of pages7
JournalVirology
Volume446
Issue number1-2
DOIs
StatePublished - Nov 1 2013

Keywords

  • Erythroid
  • Erythrovirus
  • Estrogen
  • Hormone
  • Hormone receptor
  • Nuclear receptor
  • Parvovirus
  • Retinoid
  • Thyroid

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