TY - JOUR
T1 - Human papillomavirus infection and survival in oral squamous cell cancer
T2 - A population-based study
AU - Schwartz, Seth R.
AU - Yueh, Bevan
AU - McDougall, James K.
AU - Daling, Janet R.
AU - Schwartz, Stephen M.
PY - 2001/7
Y1 - 2001/7
N2 - OBJECTIVE: To determine whether human papillomavirus (HPV) type 16 affects survival in oral squamous cell carcinoma. STUDY DESIGN: Two hundred fifty-four patients diagnosed with primary oral cancer were studied for survival in relation to tumor HPV type 16 status. Kaplan-Meier analysis and Cox proportional hazard models were used to assess survival and estimate hazard ratios adjusted for potential confounders. RESULTS: HPV type 16 DNA was detected in 15.1 % of tumors. HPV 16 positive patients had significantly reduced all-cause mortality (hazard ratio (HR) estimates = 0.34,95% Cl = 0.14,0.83) and disease-specific mortality (HR = 0.17, 95% Cl = 0.04, 0.76) compared with HPV 16 negative patients after adjustment for age, stage, treatment, smoking, alcohol, education, and comorbid disease. CONCLUSIONS: The presence of HPV type 16 DNA is independently associated with a favorable prognosis in patients with oral squamous cell carcinoma. CLINICAL SIGNIFICANCE: Although HPV genotyping is currently not widely available, it may provide important prognostic information.
AB - OBJECTIVE: To determine whether human papillomavirus (HPV) type 16 affects survival in oral squamous cell carcinoma. STUDY DESIGN: Two hundred fifty-four patients diagnosed with primary oral cancer were studied for survival in relation to tumor HPV type 16 status. Kaplan-Meier analysis and Cox proportional hazard models were used to assess survival and estimate hazard ratios adjusted for potential confounders. RESULTS: HPV type 16 DNA was detected in 15.1 % of tumors. HPV 16 positive patients had significantly reduced all-cause mortality (hazard ratio (HR) estimates = 0.34,95% Cl = 0.14,0.83) and disease-specific mortality (HR = 0.17, 95% Cl = 0.04, 0.76) compared with HPV 16 negative patients after adjustment for age, stage, treatment, smoking, alcohol, education, and comorbid disease. CONCLUSIONS: The presence of HPV type 16 DNA is independently associated with a favorable prognosis in patients with oral squamous cell carcinoma. CLINICAL SIGNIFICANCE: Although HPV genotyping is currently not widely available, it may provide important prognostic information.
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U2 - 10.1067/mhn.2001.116979
DO - 10.1067/mhn.2001.116979
M3 - Article
C2 - 11458206
AN - SCOPUS:0035408307
SN - 0194-5998
VL - 125
SP - 1
EP - 9
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
IS - 1
ER -
