Human-origin influenza A(H3N2) reassortant viruses in Swine, southeast Mexico

Martha I. Nelson, Carine K. Souza, Nídia S. Trovão, Andres Diaz, Ignacio Mena, Albert Rovira, Amy L. Vincent, Montse Torremorell, Douglas Marthaler, Marie R Culhane

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The genetic diversity of influenza A viruses circulating in swine in Mexico complicates control efforts in animals and presents a threat to humans, as shown by influenza A(H1N1)pdm09 virus. To describe evolution of swine influenza A viruses in Mexico and evaluate strains for vaccine development, we sequenced the genomes of 59 viruses and performed antigenic cartography on strains from 5 regions. We found that genetic and antigenic diversity were particularly high in southeast Mexico because of repeated introductions of viruses from humans and swine in other regions in Mexico. We identified novel reassortant H3N2 viruses with genome segments derived from 2 different viruses that were independently introduced from humans into swine: pandemic H1N1 viruses and seasonal H3N2 viruses. The Mexico swine viruses are antigenically distinct from US swine lineages. Protection against these viruses is unlikely to be afforded by US virus vaccines and would require development of new vaccines specifically targeting these diverse strains.

Original languageEnglish (US)
Pages (from-to)691-700
Number of pages10
JournalEmerging infectious diseases
Volume25
Issue number4
DOIs
StatePublished - Apr 1 2019

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Reassortant Viruses
H3N2 Subtype Influenza A Virus
Mexico
Human Influenza
Swine
Viruses
H1N1 Subtype Influenza A Virus
Vaccines
Influenza A virus
Genome
Antigenic Variation
Pandemics

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Human-origin influenza A(H3N2) reassortant viruses in Swine, southeast Mexico. / Nelson, Martha I.; Souza, Carine K.; Trovão, Nídia S.; Diaz, Andres; Mena, Ignacio; Rovira, Albert; Vincent, Amy L.; Torremorell, Montse; Marthaler, Douglas; Culhane, Marie R.

In: Emerging infectious diseases, Vol. 25, No. 4, 01.04.2019, p. 691-700.

Research output: Contribution to journalArticle

Nelson, Martha I. ; Souza, Carine K. ; Trovão, Nídia S. ; Diaz, Andres ; Mena, Ignacio ; Rovira, Albert ; Vincent, Amy L. ; Torremorell, Montse ; Marthaler, Douglas ; Culhane, Marie R. / Human-origin influenza A(H3N2) reassortant viruses in Swine, southeast Mexico. In: Emerging infectious diseases. 2019 ; Vol. 25, No. 4. pp. 691-700.
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