Human Obesity Attenuates Cardioprotection Conferred by Adipose Tissue–Derived Mesenchymal Stem/Stromal Cells

Shasha Yu, Nattawat Klomjit, Kai Jiang, Xiang Y. Zhu, Christopher M. Ferguson, Sabena M. Conley, Yasin Obeidat, Todd A. Kellogg, Travis McKenzie, Julie K. Heimbach, Amir Lerman, Lilach O. Lerman

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To explore the impact of obesity on reparative potency of adipose tissue–derived mesenchymal stromal/stem cells (A-MSC) in hypertensive cardiomyopathy, A-MSC were harvested from subcutaneous fat of obese and age-matched non-obese human subjects during bariatric or kidney donation surgeries, and then injected into mice 2 weeks after inducing renovascular hypertension (RVH) or sham surgery. Two weeks later, left ventricular (LV) function and deformation were estimated in vivo by micro-magnetic resonance imaging and myocardial damage ex vivo. Blood pressure and myocardial wall thickening were elevated in RVH + Vehicle and normalized only by lean-A-MSC. Both A-MSC types reduced LV mass and normalized the reduced LV peak strain radial in RVH, yet obese-A-MSC also impaired LV systolic function. A-MSC alleviated myocardial tissue damage in RVH, but lean-A-MSC decreased oxidative stress more effectively. Obese-A-MSC also showed increased cellular inflammation in vitro. Therefore, obese-A-MSC are less effective than lean-A-MSC in blunting hypertensive cardiomyopathy in mice with RVH.

Original languageEnglish (US)
Pages (from-to)221-232
Number of pages12
JournalJournal of cardiovascular translational research
Issue number1
StatePublished - Feb 2023

Bibliographical note

Funding Information:
This study was partly supported by National Institutes of Health grant numbers DK120292, DK122734, and AG062104. Shasha Yu was sponsored by the China Scholarship Council (#201908210044).

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.


  • Adipose-derived mesenchymal stem cells
  • Cardiac function
  • Hypertension
  • Obesity
  • Regional deformation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural


Dive into the research topics of 'Human Obesity Attenuates Cardioprotection Conferred by Adipose Tissue–Derived Mesenchymal Stem/Stromal Cells'. Together they form a unique fingerprint.

Cite this