Human neutrophil peptide in lung chronic allograft dysfunction

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Context: Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients. Objective: To prospectively validate HNP as a biomarker for BOS. Materials and methods: HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients. Results: The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p=0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time. Conclusion: HNP levels are elevated early and persistently in those that develop BOS.

Original languageEnglish (US)
Pages (from-to)663-669
Number of pages7
JournalBiomarkers
Volume16
Issue number8
DOIs
StatePublished - Dec 1 2011

Fingerprint

Bronchiolitis Obliterans
Allografts
Neutrophils
Lung
Peptides
Transplants
Biomarkers
Bronchoalveolar Lavage Fluid
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Fluids
Survival

Keywords

  • Biomarkers
  • Lung transplant
  • Rejection

Cite this

Human neutrophil peptide in lung chronic allograft dysfunction. / Reilly, Cavan S; Cervenka, Tree; Hertz, Marshall I; Becker, Trisha; Wendt, Christine H.

In: Biomarkers, Vol. 16, No. 8, 01.12.2011, p. 663-669.

Research output: Contribution to journalArticle

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