Human muscle in gene edited pigs for treatment of volumetric muscle loss

Sarah M. Greising; Joshua I. Weiner; Daniel J. Garry; David H. Sachs; Mary G. Garry

doi:10.3389/fgene.2022.948496

Human muscle in gene edited pigs for treatment of volumetric muscle loss

Sarah M. Greising, Joshua I. Weiner, Daniel J. Garry, David H. Sachs, Mary G. Garry

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.

Original language	English (US)
Article number	948496
Journal	Frontiers in Genetics
Volume	13
DOIs	https://doi.org/10.3389/fgene.2022.948496
State	Published - Jul 25 2022

Bibliographical note

Funding Information:
Grant funding from the Department of Defense (OR180095 and 12975188) to MG; Department of Defense 12974858) to DG; Department of Defense (12975087) to DS. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense.

Publisher Copyright:
Copyright © 2022 Greising, Weiner, Garry, Sachs and Garry.

Keywords

blastocyst complementation
human animal chimeras
skeletal muscle function
somatic cell nuclear transfer
xenotransplantation

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10.3389/fgene.2022.948496

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title = "Human muscle in gene edited pigs for treatment of volumetric muscle loss",

abstract = "Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.",

keywords = "blastocyst complementation, human animal chimeras, skeletal muscle function, somatic cell nuclear transfer, xenotransplantation",

author = "Greising, {Sarah M.} and Weiner, {Joshua I.} and Garry, {Daniel J.} and Sachs, {David H.} and Garry, {Mary G.}",

note = "Funding Information: Grant funding from the Department of Defense (OR180095 and 12975188) to MG; Department of Defense 12974858) to DG; Department of Defense (12975087) to DS. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense. Publisher Copyright: Copyright {\textcopyright} 2022 Greising, Weiner, Garry, Sachs and Garry.",

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doi = "10.3389/fgene.2022.948496",

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AU - Greising, Sarah M.

AU - Weiner, Joshua I.

AU - Garry, Daniel J.

AU - Sachs, David H.

AU - Garry, Mary G.

N1 - Funding Information: Grant funding from the Department of Defense (OR180095 and 12975188) to MG; Department of Defense 12974858) to DG; Department of Defense (12975087) to DS. Opinions, interpretations, conclusions and recommendations are those of the authors and are not necessarily endorsed by the Department of Defense. Publisher Copyright: Copyright © 2022 Greising, Weiner, Garry, Sachs and Garry.

PY - 2022/7/25

Y1 - 2022/7/25

N2 - Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.

AB - Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.

KW - blastocyst complementation

KW - human animal chimeras

KW - skeletal muscle function

KW - somatic cell nuclear transfer

KW - xenotransplantation

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DO - 10.3389/fgene.2022.948496

M3 - Review article

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SN - 1664-8021

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JO - Frontiers in Genetics

JF - Frontiers in Genetics

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Human muscle in gene edited pigs for treatment of volumetric muscle loss

Abstract

Bibliographical note

Keywords

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