Human llamas. Adaptation to altitude in subjects with high hemoglobin oxygen affinity

Robert P Hebbel, J. W. Eaton, R. S. Kronenberg, E. D. Zanjani, L. G. Moore, E. M. Berger

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


To assess the adaptive value of the right-shift of the hemoglobin dissociation curve (decreased affinity for oxygen) observed in humans upon altitude exposure, the short-term physiologic responses to altitude-induced hypoxia were evaluated in two subjects with a high oxygen affinity hemoglobin (Hb Andrew-Minneapolis) and in two of their normal siblings. In striking contrast to normal subjects, at moderately high altitude (3,100 m) the high affinity subjects manifested: (a) lesser increments in resting heart rate; (b) minimal increases in plasma and urinary erythropoietin; (c) no decrement in maximal oxygen consumption; and (d) no thrombocytopenia. There was no difference between subject pairs in 2,3-diphosphoglycerate response to altitude exposure. These results tend to contradict the belief that a decrease in hemoglobin oxygen affinity is of adaptive value to humans at moderate altitudes. Rather, they support the hypothesis that, despite disadvantages at low altitude, a left-shifted oxyhemoglobin dissociation curve may confer a degree of preadaptation to altitude.

Original languageEnglish (US)
Pages (from-to)593-600
Number of pages8
JournalUnknown Journal
Issue number3
StatePublished - 1978


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