Abstract
The human leukocyte antigen (HLA) is the most polymorphic genetic complex in the human genome, has been extensively studied, and has been associated with the predisposition to different autoimmune diseases. The HLA plays a pivotal role in the adaptive immune system placing it at a central role in the initiation and perpetuation of autoimmune diseases. Extensive genetic studies have isolated the role of HLA in autoimmune diseases. However, these mechanisms have not yet been integrated into a governing process in each disease to give a full explanation of the pathogenesis and course of the diseases. In this chapter, the role of HLA in autoimmune diseases will be discussed.
| Original language | English (US) |
|---|---|
| Title of host publication | Translational Autoimmunity |
| Subtitle of host publication | Etiology of Autoimmune Diseases |
| Publisher | Elsevier |
| Pages | 255-263 |
| Number of pages | 9 |
| ISBN (Electronic) | 9780128225646 |
| DOIs | |
| State | Published - Jan 1 2021 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 Elsevier Inc. All rights reserved.
Keywords
- Autoimmunity
- Genetic predisposition of disease
- Genetics
- HLA
- Pathogenesis of disease