Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes as a Model for Heart Development and Congenital Heart Disease

Michelle J. Doyle, Jamie L. Lohr, Christopher S. Chapman, Naoko Koyano-Nakagawa, Mary G. Garry, Daniel J. Garry

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Congenital heart disease (CHD) remains a significant health problem, with a growing population of survivors with chronic disease. Despite intense efforts to understand the genetic basis of CHD in humans, the etiology of most CHD is unknown. Furthermore, new models of CHD are required to better understand the development of CHD and to explore novel therapies for this patient population. In this review, we highlight the role that human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes can serve to enhance our understanding of the development, pathophysiology and potential therapeutic targets for CHD. We highlight the use of hiPSC-derived cardiomyocytes to model gene regulatory interactions, cell-cell interactions and tissue interactions contributing to CHD. We further emphasize the importance of using hiPSC-derived cardiomyocytes as personalized research models. The use of hiPSCs presents an unprecedented opportunity to generate disease-specific cellular models, investigate the underlying molecular mechanisms of disease and uncover new therapeutic targets for CHD.

Original languageEnglish (US)
Pages (from-to)710-727
Number of pages18
JournalStem Cell Reviews and Reports
Volume11
Issue number5
DOIs
StatePublished - Oct 10 2015

Keywords

  • Cardiomyocytes
  • Congenital heart disease
  • Heart development
  • Human induced pluripotent stem cells
  • Tissue engineering

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