Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods

Celso Bianco; Joan Uehlinger; Harold S. Kalpan; Fernando Aiuti; Fabrizio Ensoli; Valeria Fiorelli; C. Robert Horsburgh; Chin Yih ou; Scott D. Holmberg; Gerald Schochetman; Harold W. Jaffe; Alan R. Lifson; George W. Rutherford; li Zhen Pan; Rachel Royce; Warren Winkelstein; Jay A. Levy; Thomas F. Zuck; David T. Imagawa; Moon H. Lee; Barbara Visscher; Janice Dudley; Roger Detels

doi:10.1056/NEJM198912143212412

Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods

Celso Bianco, Joan Uehlinger, Harold S. Kalpan, Fernando Aiuti, Fabrizio Ensoli, Valeria Fiorelli, C. Robert Horsburgh, Chin Yih ou, Scott D. Holmberg, Gerald Schochetman, Harold W. Jaffe, Alan R. Lifson, George W. Rutherford, li Zhen Pan, Rachel Royce, Warren Winkelstein, Jay A. Levy, Thomas F. Zuck, David T. Imagawa, Moon H. LeeBarbara Visscher, Janice Dudley, Roger Detels

Epidemiology & Community Health

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

To the Editor: Imagawa et al. (June 1 issue)¹ reported that some persons infected with human immunodeficiency virus type 1 (HIV-1) may remain seronegative for prolonged periods. Haseltine,² in an accompanying editorial, reviewed regulatory viral genes that may explain silent HIV-1 infections. The authors of both articles commented on the potential relevance of these findings to the safety of the blood supply. Unfortunately, they did not provide data addressing the differences between the criteria used in their epidemiologic study and well-established procedures currently applied in screening blood donors. For instance, the authors considered as negative all samples that were reactive….

Original language	English (US)
Pages (from-to)	1678-1681
Number of pages	4
Journal	New England Journal of Medicine
Volume	321
Issue number	24
DOIs	https://doi.org/10.1056/NEJM198912143212412
State	Published - Dec 14 1989

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Bianco, C., Uehlinger, J., Kalpan, H. S., Aiuti, F., Ensoli, F., Fiorelli, V., Horsburgh, C. R., ou, C. Y., Holmberg, S. D., Schochetman, G., Jaffe, H. W., Lifson, A. R., Rutherford, G. W., Pan, L. Z., Royce, R., Winkelstein, W., Levy, J. A., Zuck, T. F., Imagawa, D. T., ... Detels, R. (1989). Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods. New England Journal of Medicine, 321(24), 1678-1681. https://doi.org/10.1056/NEJM198912143212412

Bianco, C, Uehlinger, J, Kalpan, HS, Aiuti, F, Ensoli, F, Fiorelli, V, Horsburgh, CR, ou, CY, Holmberg, SD, Schochetman, G, Jaffe, HW, Lifson, AR, Rutherford, GW, Pan, LZ, Royce, R, Winkelstein, W, Levy, JA, Zuck, TF, Imagawa, DT, Lee, MH, Visscher, B, Dudley, J & Detels, R 1989, 'Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods', New England Journal of Medicine, vol. 321, no. 24, pp. 1678-1681. https://doi.org/10.1056/NEJM198912143212412

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title = "Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods",

abstract = "To the Editor: Imagawa et al. (June 1 issue)1 reported that some persons infected with human immunodeficiency virus type 1 (HIV-1) may remain seronegative for prolonged periods. Haseltine,2 in an accompanying editorial, reviewed regulatory viral genes that may explain silent HIV-1 infections. The authors of both articles commented on the potential relevance of these findings to the safety of the blood supply. Unfortunately, they did not provide data addressing the differences between the criteria used in their epidemiologic study and well-established procedures currently applied in screening blood donors. For instance, the authors considered as negative all samples that were reactive….",

author = "Celso Bianco and Joan Uehlinger and Kalpan, {Harold S.} and Fernando Aiuti and Fabrizio Ensoli and Valeria Fiorelli and Horsburgh, {C. Robert} and ou, {Chin Yih} and Holmberg, {Scott D.} and Gerald Schochetman and Jaffe, {Harold W.} and Lifson, {Alan R.} and Rutherford, {George W.} and Pan, {li Zhen} and Rachel Royce and Warren Winkelstein and Levy, {Jay A.} and Zuck, {Thomas F.} and Imagawa, {David T.} and Lee, {Moon H.} and Barbara Visscher and Janice Dudley and Roger Detels",

year = "1989",

month = dec,

day = "14",

doi = "10.1056/NEJM198912143212412",

language = "English (US)",

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TY - JOUR

T1 - Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods

AU - Bianco, Celso

AU - Uehlinger, Joan

AU - Kalpan, Harold S.

AU - Aiuti, Fernando

AU - Ensoli, Fabrizio

AU - Fiorelli, Valeria

AU - Horsburgh, C. Robert

AU - ou, Chin Yih

AU - Holmberg, Scott D.

AU - Schochetman, Gerald

AU - Jaffe, Harold W.

AU - Lifson, Alan R.

AU - Rutherford, George W.

AU - Pan, li Zhen

AU - Royce, Rachel

AU - Winkelstein, Warren

AU - Levy, Jay A.

AU - Zuck, Thomas F.

AU - Imagawa, David T.

AU - Lee, Moon H.

AU - Visscher, Barbara

AU - Dudley, Janice

AU - Detels, Roger

PY - 1989/12/14

Y1 - 1989/12/14

N2 - To the Editor: Imagawa et al. (June 1 issue)1 reported that some persons infected with human immunodeficiency virus type 1 (HIV-1) may remain seronegative for prolonged periods. Haseltine,2 in an accompanying editorial, reviewed regulatory viral genes that may explain silent HIV-1 infections. The authors of both articles commented on the potential relevance of these findings to the safety of the blood supply. Unfortunately, they did not provide data addressing the differences between the criteria used in their epidemiologic study and well-established procedures currently applied in screening blood donors. For instance, the authors considered as negative all samples that were reactive….

AB - To the Editor: Imagawa et al. (June 1 issue)1 reported that some persons infected with human immunodeficiency virus type 1 (HIV-1) may remain seronegative for prolonged periods. Haseltine,2 in an accompanying editorial, reviewed regulatory viral genes that may explain silent HIV-1 infections. The authors of both articles commented on the potential relevance of these findings to the safety of the blood supply. Unfortunately, they did not provide data addressing the differences between the criteria used in their epidemiologic study and well-established procedures currently applied in screening blood donors. For instance, the authors considered as negative all samples that were reactive….

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M3 - Letter

C2 - 2586571

AN - SCOPUS:0024844580

SN - 0028-4793

VL - 321

SP - 1678

EP - 1681

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 24

ER -

Human Immunodeficiency Virus Type 1 Infection in Homosexual Men Who Remain Seronegative for Prolonged Periods

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