Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

Dawn M. Dudley; Michelle R. Koenig; Laurel M. Stewart; Matthew R. Semler; Christina M. Newman; Phoenix M. Shepherd; Keisuke Yamamoto; Meghan E. Breitbach; Michele Schotzko; Sarah Kohn; Kathleen M. Antony; Hongyu Qiu; Priyadarshini Tunga; Deborah M. Anderson; Wendi Guo; Maria Dennis; Tulika Singh; Sierra Rybarczyk; Andrea M. Weiler; Elaina Razo; Ann Mitzey; Xiankun Zeng; Jens C. Eickhoff; Emma L. Mohr; Heather A. Simmons; Michael K. Fritsch; Andres Mejia; Matthew T. Aliota; Thomas C. Friedrich; Thaddeus G. Golos; Shantha Kodihalli; Sallie R. Permar; David H. O’Connor

doi:10.1371/journal.pone.0266664

Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

Dawn M. Dudley
, Michelle R. Koenig
, Laurel M. Stewart
, Matthew R. Semler
, Christina M. Newman
, Phoenix M. Shepherd
, Keisuke Yamamoto
, Meghan E. Breitbach
, Michele Schotzko
, Sarah Kohn
, Kathleen M. Antony
, Hongyu Qiu
, Priyadarshini Tunga
, Deborah M. Anderson
, Wendi Guo
, Maria Dennis
, Tulika Singh
, Sierra Rybarczyk
, Andrea M. Weiler
, Elaina Razo

Ann Mitzey, Xiankun Zeng, Jens C. Eickhoff, Emma L. Mohr, Heather A. Simmons, Michael K. Fritsch, Andres Mejia, Matthew T. Aliota, Thomas C. Friedrich, Thaddeus G. Golos, Shantha Kodihalli, Sallie R. Permar, David H. O’Connor

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.

Original language	English (US)
Article number	e0266664
Journal	PloS one
Volume	17
Issue number	7 July
DOIs	https://doi.org/10.1371/journal.pone.0266664
State	Published - Jul 2022

Bibliographical note

Publisher Copyright:
© 2022 Dudley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Female
Humans
Immunoglobulins
Infant
Macaca mulatta
Pregnancy
Pregnancy Complications, Infectious
Viremia
Zika Virus
Zika Virus Infection

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

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10.1371/journal.pone.0266664

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Dudley, D. M., Koenig, M. R., Stewart, L. M., Semler, M. R., Newman, C. M., Shepherd, P. M., Yamamoto, K., Breitbach, M. E., Schotzko, M., Kohn, S., Antony, K. M., Qiu, H., Tunga, P., Anderson, D. M., Guo, W., Dennis, M., Singh, T., Rybarczyk, S., Weiler, A. M., ... O’Connor, D. H. (2022). Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques. PloS one, 17(7 July), Article e0266664. https://doi.org/10.1371/journal.pone.0266664

Dudley, DM, Koenig, MR, Stewart, LM, Semler, MR, Newman, CM, Shepherd, PM, Yamamoto, K, Breitbach, ME, Schotzko, M, Kohn, S, Antony, KM, Qiu, H, Tunga, P, Anderson, DM, Guo, W, Dennis, M, Singh, T, Rybarczyk, S, Weiler, AM, Razo, E, Mitzey, A, Zeng, X, Eickhoff, JC, Mohr, EL, Simmons, HA, Fritsch, MK, Mejia, A, Aliota, MT, Friedrich, TC, Golos, TG, Kodihalli, S, Permar, SR & O’Connor, DH 2022, 'Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques', PloS one, vol. 17, no. 7 July, e0266664. https://doi.org/10.1371/journal.pone.0266664

@article{38ce7f0598574f8da5e0e6d10a2e2bf0,

title = "Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques",

abstract = "There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.",

keywords = "Animals, Female, Humans, Immunoglobulins, Infant, Macaca mulatta, Pregnancy, Pregnancy Complications, Infectious, Viremia, Zika Virus, Zika Virus Infection",

author = "Dudley, \{Dawn M.\} and Koenig, \{Michelle R.\} and Stewart, \{Laurel M.\} and Semler, \{Matthew R.\} and Newman, \{Christina M.\} and Shepherd, \{Phoenix M.\} and Keisuke Yamamoto and Breitbach, \{Meghan E.\} and Michele Schotzko and Sarah Kohn and Antony, \{Kathleen M.\} and Hongyu Qiu and Priyadarshini Tunga and Anderson, \{Deborah M.\} and Wendi Guo and Maria Dennis and Tulika Singh and Sierra Rybarczyk and Weiler, \{Andrea M.\} and Elaina Razo and Ann Mitzey and Xiankun Zeng and Eickhoff, \{Jens C.\} and Mohr, \{Emma L.\} and Simmons, \{Heather A.\} and Fritsch, \{Michael K.\} and Andres Mejia and Aliota, \{Matthew T.\} and Friedrich, \{Thomas C.\} and Golos, \{Thaddeus G.\} and Shantha Kodihalli and Permar, \{Sallie R.\} and O{\textquoteright}Connor, \{David H.\}",

note = "Publisher Copyright: {\textcopyright} 2022 Dudley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2022",

month = jul,

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AU - Koenig, Michelle R.

AU - Stewart, Laurel M.

AU - Semler, Matthew R.

AU - Newman, Christina M.

AU - Shepherd, Phoenix M.

AU - Yamamoto, Keisuke

AU - Breitbach, Meghan E.

AU - Schotzko, Michele

AU - Kohn, Sarah

AU - Antony, Kathleen M.

AU - Qiu, Hongyu

AU - Tunga, Priyadarshini

AU - Anderson, Deborah M.

AU - Guo, Wendi

AU - Dennis, Maria

AU - Singh, Tulika

AU - Rybarczyk, Sierra

AU - Weiler, Andrea M.

AU - Razo, Elaina

AU - Mitzey, Ann

AU - Zeng, Xiankun

AU - Eickhoff, Jens C.

AU - Mohr, Emma L.

AU - Simmons, Heather A.

AU - Fritsch, Michael K.

AU - Mejia, Andres

AU - Aliota, Matthew T.

AU - Friedrich, Thomas C.

AU - Golos, Thaddeus G.

AU - Kodihalli, Shantha

AU - Permar, Sallie R.

AU - O’Connor, David H.

N1 - Publisher Copyright: © 2022 Dudley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2022/7

Y1 - 2022/7

N2 - There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.

AB - There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.

KW - Animals

KW - Female

KW - Humans

KW - Immunoglobulins

KW - Infant

KW - Macaca mulatta

KW - Pregnancy

KW - Pregnancy Complications, Infectious

KW - Viremia

KW - Zika Virus

KW - Zika Virus Infection

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UR - https://www.scopus.com/pages/publications/85134149047#tab=citedBy

U2 - 10.1371/journal.pone.0266664

DO - 10.1371/journal.pone.0266664

M3 - Article

C2 - 35834540

AN - SCOPUS:85134149047

SN - 1932-6203

VL - 17

JO - PloS one

JF - PloS one

IS - 7 July

M1 - e0266664

ER -

Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

Abstract

Bibliographical note

UN SDGs

Keywords

PubMed: MeSH publication types

Publisher link

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