TY - JOUR
T1 - Human Histologic and Histomorphometric Analysis Comparing OsteoGraf/N with PepGen P-15 in the Maxillary Sinus Elevation Procedure
T2 - A Case Report
AU - Krauser, Jack T.
AU - Rohrer, Michael D.
AU - Wallace, Stephen S.
PY - 2000
Y1 - 2000
N2 - The use of the anorganic bovine bone mineral OsteoGraf/N combined with demineralized freeze-dried bone allograft has received widespread use in sinus elevations. This composite graft material has proven to be suitable, predictable, and successful for the placement and integration of endosseous implants in the edentulous, atrophic maxilla.In this case study, the current materials and accepted methodology were compared with the latest tissue-engineered bone replacement graft material, PepGen P-15. PepGen P-15 is a combination of OsteoGraf/N and a synthetic peptide (P-15) that mimics the cell-binding domain of Type-I collagen responsible for cell migration, differentiation, and proliferation.The radiographic, histologic, and histomorphometric evaluations of the sinus grafted with PepGen P-15 showed enhanced bone formation within a shorter time interval compared with the composite graft material of OsteoGraf/N and demineralized freeze-dried bone allograft.
AB - The use of the anorganic bovine bone mineral OsteoGraf/N combined with demineralized freeze-dried bone allograft has received widespread use in sinus elevations. This composite graft material has proven to be suitable, predictable, and successful for the placement and integration of endosseous implants in the edentulous, atrophic maxilla.In this case study, the current materials and accepted methodology were compared with the latest tissue-engineered bone replacement graft material, PepGen P-15. PepGen P-15 is a combination of OsteoGraf/N and a synthetic peptide (P-15) that mimics the cell-binding domain of Type-I collagen responsible for cell migration, differentiation, and proliferation.The radiographic, histologic, and histomorphometric evaluations of the sinus grafted with PepGen P-15 showed enhanced bone formation within a shorter time interval compared with the composite graft material of OsteoGraf/N and demineralized freeze-dried bone allograft.
KW - Enhanced bone regeneration
KW - Vascularization
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U2 - 10.1097/00008505-200009040-00004
DO - 10.1097/00008505-200009040-00004
M3 - Article
C2 - 11307551
AN - SCOPUS:0034570062
VL - 9
SP - 298
EP - 301
JO - The International journal of oral implantology : implantologist
JF - The International journal of oral implantology : implantologist
SN - 1056-6163
IS - 4
ER -