Human hippocampal long-term sustained response during word memory processing

Toshinori Kato, Peter Erhard, Yoshihiro Takayama, John Strupp, Tuong Huu Le, Seiji Ogawa, Kamil Ugurbil

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

TEMPORAL behavior of activation associated with the neural substrate of human memory function was investigated during and after an auditorily instructed word memory task using multislice functional magnetic resonance imaging. The hippocampal formation, which is involved in human memory function, displayed a long-term sustained response that persisted significantly (-90 s) beyond the duration of the memory task. This sustained period was -two-fold longer than the duration of the post-task activation observed in auditory areas and Broca's area, which are involved in the phonological loop of the verbal working memory. These observations suggest that the hippocampal memory processing involves sustained activation in the transitional function for the long-term memory over the working memory period.

Original languageEnglish (US)
Pages (from-to)1041-1047
Number of pages7
JournalNeuroreport
Volume9
Issue number6
DOIs
StatePublished - Apr 20 1998

Keywords

  • Brain
  • Cerebral multiphasic sustained response
  • Echo-planar imaging (EPI)
  • Functional magnetic resonance imaging (fMRI)
  • Hippocampus
  • Humans
  • Long- term sustained response
  • Memory
  • Network

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