Human hippocampal activation during transitive inference

Jennifer C. Nagode, José V. Pardo

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The medial temporal lobe contains multiple structures whose mnemonic operations need further delineation. One model posits the function of the hippocampus as a relational binder, collaborating with overlying cortices that perform encoding and retrieval operations. For instance, lesions of the hippocampus leave intact the learning of paired-associates while impairing the ability to synthesize information across pairs. We test this relational model with two PET studies of normal humans during a transitive inference task using faces that either have or lack relationships across the stimulus pairs. Both studies converge to support a relational processing model of hippocampal function.

Original languageEnglish (US)
Pages (from-to)939-944
Number of pages6
Issue number7
StatePublished - May 24 2002
Externally publishedYes


  • Face processing
  • Hippocampus
  • Medial temporal lobe
  • Memory
  • Positron emission tomography
  • Reasoning


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