Human hepatocyte growth factor in alcoholic liver disease: A comparison with change in α-fetoprotein

Charles L. Mendenhall, Filip Roos, Thomas E. Moritz, Gary A. Roselle, Antonio Chedid, Charles J. Grossman, Susan D. Rouster, Gregory L. Bennett, John R. Lake

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

To evaluate the hepatic regenerative response in patients with alcoholic liver disease, sera from 263 patients with severe alcoholic hepatitis and/or cirrhosis were analyzed for hepatocyte growth factor (HGF) and α-fetoprotein (AFP). HGF concentration was elevated above healthy controls in 95% of the patients (median level = 2.4 ng/ml), whereas AFP tended to be depressed below controls (median level = 4.1 ng/ml). Correlations with parameters of liver injury (i.e., ascites, encephalopathy, AST bilirubin, and protime) all showed a more significant correlation with HGF concentrations then those of AFP. Patients with HGF levels below the mean (4 ng/ml) exhibited significantly better survival (median survival = 35 months vs. 8.5 months for those with HGF ≤4 ng/ml; p = 0.007). Serum HGF levels were associated with various specific histologic features of alcoholic hepatitis that included, but were not exclusively related to, necrosis.

Original languageEnglish (US)
Pages (from-to)1625-1630
Number of pages6
JournalAlcoholism: Clinical and Experimental Research
Volume20
Issue number9
DOIs
StatePublished - Dec 1 1996

Keywords

  • Alcoholic Liver Disease
  • Hepatocyte Growth Factor
  • α-Fetoprotein

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