TY - JOUR
T1 - Human hepatocyte growth factor in alcoholic liver disease
T2 - A comparison with change in α-fetoprotein
AU - Mendenhall, Charles L.
AU - Roos, Filip
AU - Moritz, Thomas E.
AU - Roselle, Gary A.
AU - Chedid, Antonio
AU - Grossman, Charles J.
AU - Rouster, Susan D.
AU - Bennett, Gregory L.
AU - Lake, John R.
PY - 1996
Y1 - 1996
N2 - To evaluate the hepatic regenerative response in patients with alcoholic liver disease, sera from 263 patients with severe alcoholic hepatitis and/or cirrhosis were analyzed for hepatocyte growth factor (HGF) and α-fetoprotein (AFP). HGF concentration was elevated above healthy controls in 95% of the patients (median level = 2.4 ng/ml), whereas AFP tended to be depressed below controls (median level = 4.1 ng/ml). Correlations with parameters of liver injury (i.e., ascites, encephalopathy, AST bilirubin, and protime) all showed a more significant correlation with HGF concentrations then those of AFP. Patients with HGF levels below the mean (4 ng/ml) exhibited significantly better survival (median survival = 35 months vs. 8.5 months for those with HGF ≤4 ng/ml; p = 0.007). Serum HGF levels were associated with various specific histologic features of alcoholic hepatitis that included, but were not exclusively related to, necrosis.
AB - To evaluate the hepatic regenerative response in patients with alcoholic liver disease, sera from 263 patients with severe alcoholic hepatitis and/or cirrhosis were analyzed for hepatocyte growth factor (HGF) and α-fetoprotein (AFP). HGF concentration was elevated above healthy controls in 95% of the patients (median level = 2.4 ng/ml), whereas AFP tended to be depressed below controls (median level = 4.1 ng/ml). Correlations with parameters of liver injury (i.e., ascites, encephalopathy, AST bilirubin, and protime) all showed a more significant correlation with HGF concentrations then those of AFP. Patients with HGF levels below the mean (4 ng/ml) exhibited significantly better survival (median survival = 35 months vs. 8.5 months for those with HGF ≤4 ng/ml; p = 0.007). Serum HGF levels were associated with various specific histologic features of alcoholic hepatitis that included, but were not exclusively related to, necrosis.
KW - Alcoholic Liver Disease
KW - Hepatocyte Growth Factor
KW - α-Fetoprotein
UR - http://www.scopus.com/inward/record.url?scp=0030470474&partnerID=8YFLogxK
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U2 - 10.1111/j.1530-0277.1996.tb01708.x
DO - 10.1111/j.1530-0277.1996.tb01708.x
M3 - Article
C2 - 8986214
AN - SCOPUS:0030470474
SN - 0145-6008
VL - 20
SP - 1625
EP - 1630
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
IS - 9
ER -
