Human hepatic stellate cell isolation and characterization

Linshan Shang, Mojgan Hosseini, Xiao Liu, Tatiana Kisseleva, David Allen Brenner

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

The hepatic stellate cells (HSCs) localize at the space of Disse in the liver and have multiple functions. They are identified as the major contributor to hepatic fibrosis. Significant understanding of HSCs has been achieved using rodent models and isolated murine HSCs; as well as investigating human liver tissues and human HSCs. There is growing interest and need of translating rodent study findings to human HSCs and human liver diseases. However, species-related differences impose challenges on the translational research. In this review, we focus on the current information on human HSCs isolation methods, human HSCs markers, and established human HSC cell lines.

Original languageEnglish (US)
Pages (from-to)6-17
Number of pages12
JournalJournal of Gastroenterology
Volume53
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Keywords

  • Human HSC isolation
  • Human HSC markers
  • Human hepatic stellate cell lines
  • Human hepatic stellate cells

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