Human granulocytic ehrlichiosis in the United States

Johan S. Bakken

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Human granulocytic ehrlichiosis (HGE) is a tick-borne, acute, nonspecific febrile illness that was first described in 1994; 142 cases from 10 states had been diagnosed by April 1996. Characteristic inclusions (morulae) have been observed in the cytoplasm of neutrophils in 80% of patients from the upper Midwest. Polymerase chain reaction of acute-phase blood or a 4-fold or greater convalescent antibody seroconversion confirms the diagnosis. Tetracycline or doxycycline provide effective treatment and should be administered for 2 weeks to ensure sufficient treatment for HGE as well as possible Lyme borreliosis coinfection.

Original languageEnglish (US)
Pages (from-to)877-889
Number of pages13
JournalInfections in Medicine
Issue number10
StatePublished - Oct 1 1996


  • Doxycycline
  • Ehrlichia equi
  • Human granulocytic ehrlichiosis (HGE)
  • Ixodes scapularis
  • Tick-borne infections

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