Human granulocytic anaplasmosis and Anaplasma phagocytophilum

J. Stephen Dumler, Kyoung Seong Choi, Jose Carlos Garcia-Garcia, Nicole S. Barat, Diana G. Scorpio, Justin W. Garyu, Dennis J. Grab, Johan S. Bakken

Research output: Contribution to journalReview articlepeer-review

310 Scopus citations

Abstract

Human granulocytic anaplasmosis is a tickborne rickettsial infection of neutrophils caused by Anaplasma phagocytophilum. The human disease was first identified in 1990, although the pathogen was defined as a veterinary agent in 1932. Since 1990, US cases have markedly increased, and infections are now recognized in Europe. A high international seroprevalence suggests infection is widespread but unrecognized. The niche for A. phagocytophilum, the neutrophil, indicates that the pathogen has unique adaptations and pathogenetic mechanisms. Intensive study has demonstrated interactions with host-cell signal transduction and possibly eukaryotic transcription. This interaction leads to permutations of neutrophil function and could permit immunopathologic changes, severe disease, and opportunistic infections. More study is needed to define the immunology and pathogenetic mechanisms and to understand why severe disease develops in some persons and why some animals become long-term permissive reservoir hosts.

Original languageEnglish (US)
Pages (from-to)1828-1834
Number of pages7
JournalEmerging infectious diseases
Volume11
Issue number12
DOIs
StatePublished - Dec 2005

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Copyright 2018 Elsevier B.V., All rights reserved.

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