Human Granulocytic Anaplasmosis

Johan S. Bakken, J. Stephen Dumler

Research output: Contribution to journalReview articlepeer-review

161 Scopus citations


Human granulocytic anaplasmosis, a deer tick-transmitted rickettsial infection caused by Anaplasma phagocytophilum, is a common cause of undifferentiated fever in the northeast and upper Midwest United States. Patients are often initially diagnosed with a mild viral infection, and illness readily resolves in most cases. However, as many as 3% develop life-threatening complications and nearly 1% die from the infection. Although coinfections with Borrelia burgdorferi and Babesia microti occur, there is little evidence to suggest synergism of disease or a role for A phagocytophilum in chronic illness. No vaccine is available.

Original languageEnglish (US)
Pages (from-to)341-355
Number of pages15
JournalInfectious disease clinics of North America
Issue number2
StatePublished - Jun 1 2015
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by NIH R01AI44102 .

Publisher Copyright:
© 2015 Elsevier Inc.


  • Anaplasmosis
  • Diagnosis
  • Granulocytic
  • Human
  • Management


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