Human cytomegalovirus immediate-early 2 gene expression blocks virus-induced beta interferon production

R. Travis Taylor, Wade A Bresnahan

Research output: Contribution to journalArticle

89 Scopus citations

Abstract

The effect of human cytomegalovirus (HCMV) gene expression on beta interferon (IFN-β) expression was examined. We demonstrate that the HCMV immediate-early 2 (IE2) gene product IE86 can effectively block the induction of IFN-β during HCMV infection. IE86 also efficiently blocked the induction of IFN-β following Sendai virus infection, demonstrating that IE86's ability to block induction of IFN-β is not limited to HCMV infection, identifying IE2 as an IFN-β antagonist.

Original languageEnglish (US)
Pages (from-to)3873-3877
Number of pages5
JournalJournal of virology
Volume79
Issue number6
DOIs
StatePublished - Mar 1 2005

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