Human cornea organ cultures: Epithelial endothelial interactions

M. Yanoff, J. D. Cameron

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Full-thickness explants of five human corneas grown in organ culture demonstrate that the migration of epithelium and endothelium is mutually limited once contact between the two cell types has been established. Two human corneas, however, failed to show this contact inhibition, and corneal epithelium surrounded completely the explant; both corneas showed cornea guttata. The implications of corneal epithelium-endothelium contact inhibition, and the failure of such inhibition, are discussed.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
Issue number4
StatePublished - Dec 1 1977


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