Human β-endorphin: Development of tolerance and behavioral activity in rats

Liang fu Tseng; Horace H. Loh; Choh Hao Li

doi:10.1016/0006-291X(77)90316-3

Human β-endorphin: Development of tolerance and behavioral activity in rats

Liang fu Tseng
, Horace H. Loh
, Choh Hao Li

Pharmacology

Research output: Contribution to journal › Article › peer-review

92 Scopus citations

Abstract

Human β-endorphin produced a potent antinociceptive response as estimated by the tail-flick test in rats after intraventricular injection. On a molar basis, the peptide was 21 times more potent than morphine and in addition, the peptide produced morphine-like catatonia and hypothermia. These responses were blocked by naloxone. Repeated injections of the peptide induced tolerance to analgesic response, catatonia and hypothermia. Cross tolerance to morphine was also observed.

Original language	English (US)
Pages (from-to)	390-396
Number of pages	7
Journal	Biochemical and Biophysical Research Communications
Volume	74
Issue number	2
DOIs	https://doi.org/10.1016/0006-291X(77)90316-3
State	Published - Jan 24 1977

Bibliographical note

Funding Information:
by the National Institute of Drug (H.H.L.), and NIH Grant GM-2907 Institute of Mental Health Research

Publisher link

10.1016/0006-291X(77)90316-3

Find It

Find It at U of M Libraries

Cite this

@article{0ef9b8c35dea4a5da99c8d6e6f7bf225,

title = "Human β-endorphin: Development of tolerance and behavioral activity in rats",

abstract = "Human β-endorphin produced a potent antinociceptive response as estimated by the tail-flick test in rats after intraventricular injection. On a molar basis, the peptide was 21 times more potent than morphine and in addition, the peptide produced morphine-like catatonia and hypothermia. These responses were blocked by naloxone. Repeated injections of the peptide induced tolerance to analgesic response, catatonia and hypothermia. Cross tolerance to morphine was also observed.",

author = "Tseng, \{Liang fu\} and Loh, \{Horace H.\} and Li, \{Choh Hao\}",

note = "Funding Information: by the National Institute of Drug (H.H.L.), and NIH Grant GM-2907 Institute of Mental Health Research",

year = "1977",

month = jan,

day = "24",

doi = "10.1016/0006-291X(77)90316-3",

language = "English (US)",

volume = "74",

pages = "390--396",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Human β-endorphin

T2 - Development of tolerance and behavioral activity in rats

AU - Tseng, Liang fu

AU - Loh, Horace H.

AU - Li, Choh Hao

N1 - Funding Information: by the National Institute of Drug (H.H.L.), and NIH Grant GM-2907 Institute of Mental Health Research

PY - 1977/1/24

Y1 - 1977/1/24

N2 - Human β-endorphin produced a potent antinociceptive response as estimated by the tail-flick test in rats after intraventricular injection. On a molar basis, the peptide was 21 times more potent than morphine and in addition, the peptide produced morphine-like catatonia and hypothermia. These responses were blocked by naloxone. Repeated injections of the peptide induced tolerance to analgesic response, catatonia and hypothermia. Cross tolerance to morphine was also observed.

AB - Human β-endorphin produced a potent antinociceptive response as estimated by the tail-flick test in rats after intraventricular injection. On a molar basis, the peptide was 21 times more potent than morphine and in addition, the peptide produced morphine-like catatonia and hypothermia. These responses were blocked by naloxone. Repeated injections of the peptide induced tolerance to analgesic response, catatonia and hypothermia. Cross tolerance to morphine was also observed.

UR - https://www.scopus.com/pages/publications/0017332735

UR - https://www.scopus.com/pages/publications/0017332735#tab=citedBy

U2 - 10.1016/0006-291X(77)90316-3

DO - 10.1016/0006-291X(77)90316-3

M3 - Article

C2 - 836295

AN - SCOPUS:0017332735

SN - 0006-291X

VL - 74

SP - 390

EP - 396

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Human β-endorphin: Development of tolerance and behavioral activity in rats

Abstract

Bibliographical note

Publisher link

Find It

Other files and links

Fingerprint

Cite this