HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults

John L. Zenk, Joy L. Frestedt, Michael A Kuskowski

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green tea extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007) will increase the resting metabolic rate (RMR) of overweight subjects maintained on a calorie-restricted diet. In this randomized, double-blind, placebo-controlled, crossover trial, overweight adults on a calorie-restricted diet were randomized to three 7-day treatment periods with 7-Keto, HUM5007 or placebo. Resting metabolic rate was measured by indirect calorimetry at the beginning and end of each treatment period with a 7-day washout between testing periods. Of 45 subjects enrolled, 40 completed the study (30 women, 10 men; mean age, 38.5 years; mean mass index, 32.0 kg/m2). During the placebo treatment, RMR decreased by 3.9% (75±111 kcal/day; mean±S.D.); however, RMR increased significantly by 1.4% (21±115 kcal/day) and 3.4% (59±118 kcal/day) during the 7-Keto and HUM5007 treatment periods, respectively (each compared to placebo, P=.001). No significant differences were found between the treatment periods with respect to compliance or adverse events. In this study, the administration of HUM5007 or 7-Keto reversed the decrease in RMR normally associated with dieting. HUM5007 and 7-Keto increased RMR above basal levels and may benefit obese individuals with impaired energy expenditure. HUM5007 and 7-Keto were generally well tolerated and no serious adverse events were reported.

Original languageEnglish (US)
Pages (from-to)629-634
Number of pages6
JournalJournal of Nutritional Biochemistry
Volume18
Issue number9
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

Keywords

  • 3-acetyl-7-oxo-dehydroepiandrosterone
  • Clinical trial
  • Obesity
  • Resting metabolic rate
  • Weight loss

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