H3-cerebroside sulfate re-distribution induced by cation, opiate or phosphatidyl serine

Mook Cho Tae Mook Cho, Sook Cho Jung Sook Cho, Horace H. Loh

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Transfer of H3-cerebroside sulfate (CS) from aqueous phase to nonaqueous phases (heptane interface) was studied in the absence and presence of opiates, cations and phosphatidylserine. The degree of H3-CS re-distribution was dependent on the concentration of these substances used. The concentration of an opiate agonist (GPA-1657) required to increase H3-CS by 50% in the nonaqueous phase was much lower than that of its corresponding antagonist (GPA-2163) and the value for calcium was 100 times less than sodium. Opiate antagonist (GPA-2163) and phosphatidylserine inhibited the agonist induced re-distribution of H3-CS. Thus, the data seem to indicate that the distribution of H3-CS between these two phases was determined by hydrophobic-hydropholic balance of H3-CS and this balance was dependent on the counter ion pairing with CS. This finding is consistent with our previous observation that opiate agonist-CS complex was more hydrophobic than free CS of the CS-complex formed with opiate antagonist.

Original languageEnglish (US)
Pages (from-to)117-123
Number of pages7
JournalLife Sciences
Volume19
Issue number1
DOIs
StatePublished - Jul 1 1976

Fingerprint

Opiate Alkaloids
Phosphatidylserines
Cations
cerebroside sulfate
Heptanes
Radiation counters

Cite this

H3-cerebroside sulfate re-distribution induced by cation, opiate or phosphatidyl serine. / Tae Mook Cho, Mook Cho; Jung Sook Cho, Sook Cho; Loh, Horace H.

In: Life Sciences, Vol. 19, No. 1, 01.07.1976, p. 117-123.

Research output: Contribution to journalArticle

Tae Mook Cho, Mook Cho ; Jung Sook Cho, Sook Cho ; Loh, Horace H. / H3-cerebroside sulfate re-distribution induced by cation, opiate or phosphatidyl serine. In: Life Sciences. 1976 ; Vol. 19, No. 1. pp. 117-123.
@article{88a6b4bdc7bb4062a1852ed0d978cde1,
title = "H3-cerebroside sulfate re-distribution induced by cation, opiate or phosphatidyl serine",
abstract = "Transfer of H3-cerebroside sulfate (CS) from aqueous phase to nonaqueous phases (heptane interface) was studied in the absence and presence of opiates, cations and phosphatidylserine. The degree of H3-CS re-distribution was dependent on the concentration of these substances used. The concentration of an opiate agonist (GPA-1657) required to increase H3-CS by 50{\%} in the nonaqueous phase was much lower than that of its corresponding antagonist (GPA-2163) and the value for calcium was 100 times less than sodium. Opiate antagonist (GPA-2163) and phosphatidylserine inhibited the agonist induced re-distribution of H3-CS. Thus, the data seem to indicate that the distribution of H3-CS between these two phases was determined by hydrophobic-hydropholic balance of H3-CS and this balance was dependent on the counter ion pairing with CS. This finding is consistent with our previous observation that opiate agonist-CS complex was more hydrophobic than free CS of the CS-complex formed with opiate antagonist.",
author = "{Tae Mook Cho}, {Mook Cho} and {Jung Sook Cho}, {Sook Cho} and Loh, {Horace H.}",
year = "1976",
month = "7",
day = "1",
doi = "10.1016/0024-3205(76)90381-7",
language = "English (US)",
volume = "19",
pages = "117--123",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - H3-cerebroside sulfate re-distribution induced by cation, opiate or phosphatidyl serine

AU - Tae Mook Cho, Mook Cho

AU - Jung Sook Cho, Sook Cho

AU - Loh, Horace H.

PY - 1976/7/1

Y1 - 1976/7/1

N2 - Transfer of H3-cerebroside sulfate (CS) from aqueous phase to nonaqueous phases (heptane interface) was studied in the absence and presence of opiates, cations and phosphatidylserine. The degree of H3-CS re-distribution was dependent on the concentration of these substances used. The concentration of an opiate agonist (GPA-1657) required to increase H3-CS by 50% in the nonaqueous phase was much lower than that of its corresponding antagonist (GPA-2163) and the value for calcium was 100 times less than sodium. Opiate antagonist (GPA-2163) and phosphatidylserine inhibited the agonist induced re-distribution of H3-CS. Thus, the data seem to indicate that the distribution of H3-CS between these two phases was determined by hydrophobic-hydropholic balance of H3-CS and this balance was dependent on the counter ion pairing with CS. This finding is consistent with our previous observation that opiate agonist-CS complex was more hydrophobic than free CS of the CS-complex formed with opiate antagonist.

AB - Transfer of H3-cerebroside sulfate (CS) from aqueous phase to nonaqueous phases (heptane interface) was studied in the absence and presence of opiates, cations and phosphatidylserine. The degree of H3-CS re-distribution was dependent on the concentration of these substances used. The concentration of an opiate agonist (GPA-1657) required to increase H3-CS by 50% in the nonaqueous phase was much lower than that of its corresponding antagonist (GPA-2163) and the value for calcium was 100 times less than sodium. Opiate antagonist (GPA-2163) and phosphatidylserine inhibited the agonist induced re-distribution of H3-CS. Thus, the data seem to indicate that the distribution of H3-CS between these two phases was determined by hydrophobic-hydropholic balance of H3-CS and this balance was dependent on the counter ion pairing with CS. This finding is consistent with our previous observation that opiate agonist-CS complex was more hydrophobic than free CS of the CS-complex formed with opiate antagonist.

UR - http://www.scopus.com/inward/record.url?scp=0017161427&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017161427&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(76)90381-7

DO - 10.1016/0024-3205(76)90381-7

M3 - Article

C2 - 940429

AN - SCOPUS:0017161427

VL - 19

SP - 117

EP - 123

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 1

ER -