HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

Bianca Rivera-Peña; Francisco J. Ruíz-Fullana; Germán L. Vélez-Reyes; Rosa J. Rodriguez-Benitez; María J. Marcos-Martínez; Juan Trinidad-Pinedo; Adriana Báez

doi:10.1186/s13027-016-0095-4

HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

Bianca Rivera-Peña, Francisco J. Ruíz-Fullana, Germán L. Vélez-Reyes, Rosa J. Rodriguez-Benitez, María J. Marcos-Martínez, Juan Trinidad-Pinedo, Adriana Báez

Microbiology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x². Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. Results: OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. Conclusions: HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.

Original language	English (US)
Article number	47
Journal	Infectious Agents and Cancer
Volume	11
Issue number	1
DOIs	https://doi.org/10.1186/s13027-016-0095-4
State	Published - Aug 24 2016

Bibliographical note

Funding Information:
The research described was supported by the University of Puerto Rico School of Medicine Otolaryngology Section, NIH/National Cancer Institute grants P20CA91402, U54CA96297; NIH/National Institute of General Medical Sciences grant S06GM8224. This research also used core facilities supported by NIH/NCRR G12RR03051 and NIH/NIMHDD 8G12MD007600. Additionally, we want to thank Antonio Arrieta, MSII, for the assistance on the statistical part of this study.

Publisher Copyright:
© 2016 The Author(s).

Keywords

Biomarker
Head and neck squamous cell carcinoma
Human Papillomavirus (HPV)
Overall Survival (OS)
TNM

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/s13027-016-0095-4

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title = "HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients",

abstract = "Background: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x2. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. Results: OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. Conclusions: HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.",

keywords = "Biomarker, Head and neck squamous cell carcinoma, Human Papillomavirus (HPV), Overall Survival (OS), TNM",

author = "Bianca Rivera-Pe{\~n}a and Ru{\'i}z-Fullana, {Francisco J.} and V{\'e}lez-Reyes, {Germ{\'a}n L.} and Rodriguez-Benitez, {Rosa J.} and Marcos-Mart{\'i}nez, {Mar{\'i}a J.} and Juan Trinidad-Pinedo and Adriana B{\'a}ez",

note = "Funding Information: The research described was supported by the University of Puerto Rico School of Medicine Otolaryngology Section, NIH/National Cancer Institute grants P20CA91402, U54CA96297; NIH/National Institute of General Medical Sciences grant S06GM8224. This research also used core facilities supported by NIH/NCRR G12RR03051 and NIH/NIMHDD 8G12MD007600. Additionally, we want to thank Antonio Arrieta, MSII, for the assistance on the statistical part of this study. Publisher Copyright: {\textcopyright} 2016 The Author(s).",

year = "2016",

month = aug,

day = "24",

doi = "10.1186/s13027-016-0095-4",

language = "English (US)",

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journal = "Infectious Agents and Cancer",

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T1 - HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

AU - Rivera-Peña, Bianca

AU - Ruíz-Fullana, Francisco J.

AU - Vélez-Reyes, Germán L.

AU - Rodriguez-Benitez, Rosa J.

AU - Marcos-Martínez, María J.

AU - Trinidad-Pinedo, Juan

AU - Báez, Adriana

N1 - Funding Information: The research described was supported by the University of Puerto Rico School of Medicine Otolaryngology Section, NIH/National Cancer Institute grants P20CA91402, U54CA96297; NIH/National Institute of General Medical Sciences grant S06GM8224. This research also used core facilities supported by NIH/NCRR G12RR03051 and NIH/NIMHDD 8G12MD007600. Additionally, we want to thank Antonio Arrieta, MSII, for the assistance on the statistical part of this study. Publisher Copyright: © 2016 The Author(s).

PY - 2016/8/24

Y1 - 2016/8/24

N2 - Background: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x2. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. Results: OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. Conclusions: HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.

AB - Background: HPV-16 modifies the overall survival (OS) of patients with oropharyngeal cancer (OPSCC). HPV-16 has been established as risk factor for OPSCC, but HPV-16 infection may also reside in the larynx and oral cavity. We evaluated HPV-16 status on OS of Head and Neck Squamous Cell Carcinoma (HNSCC) patients. Methods: HPV-16 infection was confirmed by amplification of E6 and E7 viral oncogenes through PCR assay and E6 IHC in 185 HNSCC samples. Associations between HPV-16 status and clinicopathological parameters were performed using Fisher's exact test and x2. Survival analysis was completed using Kaplan-Meier estimator and multivariate Cox regression analysis. Results: OS of HPV-16 positive patients was longer compared to HPV-16 negative patients (P = 0.002). HPV-16 positive tumors of the larynx (LSCC) and pharynx (PSCC) showed improved OS compared to HPV-16 negative tumors. Also, HPV-16 positive patients exposed to radiotherapy presented a better survival. Conclusions: HPV-16 status has a positive prognostic value in HNSCC. Addition of HPV-16 status to the TNM staging can provide better assessment in prognosis and guide treatment for HNSCC patients.

KW - Biomarker

KW - Head and neck squamous cell carcinoma

KW - Human Papillomavirus (HPV)

KW - Overall Survival (OS)

KW - TNM

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U2 - 10.1186/s13027-016-0095-4

DO - 10.1186/s13027-016-0095-4

M3 - Article

AN - SCOPUS:84988009609

SN - 1750-9378

VL - 11

JO - Infectious Agents and Cancer

JF - Infectious Agents and Cancer

IS - 1

M1 - 47

ER -

HPV-16 infection modifies overall survival of Puerto Rican HNSCC patients

Abstract

Bibliographical note

Keywords

UN SDGs

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