How much will it hurt? HPV vaccine side effects and influence on completion of the three-dose regimen

Paul L. Reiter, Noel T. Brewer, Sami L. Gottlieb, Annie Laurie McRee, Jennifer S. Smith

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations


    We examined the prevalence of reported pain following human papillomavirus (HPV) vaccination and whether it differed from that for other adolescent vaccines or affected completion of the HPV vaccine regimen. In 2008, we conducted cross-sectional surveys with parents of adolescent girls aged 11-20 living in areas of North Carolina with elevated cervical cancer rates who had received at least one dose of HPV vaccine. Pain from HPV vaccination, while commonly reported by parents, was less frequent compared to other adolescent vaccines and did not appear to affect vaccine regimen completion. These findings may be important to increase HPV vaccination coverage.

    Original languageEnglish (US)
    Pages (from-to)6840-6844
    Number of pages5
    Issue number49
    StatePublished - Nov 16 2009

    Bibliographical note

    Funding Information:
    Although we do not believe we have any conflicts of interest, we wish to share the following information in the interest of full disclosure. NTB, the study PI, received a research grant from Merck for a study in 2008–2009 of men's attitudes toward HPV vaccination. NTB has received no honoraria or consulting fees from Merck or GlaxoSmithKline. JSS has received research grants or contracts, honoraria, or consulting fees during the last 4 years from GlaxoSmithKline and Merck. No funds from GlaxoSmithKline or Merck funded these research activities. One co-author from the funding source, the CDC, (SLG) participated in conducting the study and in preparing and submitting this article, though she did not participate in the decision to fund the study.

    Funding Information:
    This study was funded by grants from the Centers for Disease Control and Prevention ( S3715-25/25 ), the American Cancer Society ( MSRG-06-259-01-CPPB ), and the National Cancer Institute ( R25 CA57726 ).


    • HPV
    • Side effects
    • Vaccine

    PubMed: MeSH publication types

    • Journal Article
    • Research Support, N.I.H., Extramural
    • Research Support, Non-U.S. Gov't
    • Research Support, U.S. Gov't, P.H.S.


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