How might novel technologies such as optogenetics lead to better treatments in epilepsy?

Esther Krook-Magnuson, Marco Ledri, Ivan Soltesz, Merab Kokaia

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations

Abstract

Recent technological advances open exciting avenues for improving the understanding of mechanisms in a broad range of epilepsies. This chapter focuses on the development of optogenetics and on-demand technologies for the study of epilepsy and the control of seizures. Optogenetics is a technique which, through cell-type selective expression of light-sensitive proteins called opsins, allows temporally precise control via light delivery of specific populations of neurons. Therefore, it is now possible not only to record interictal and ictal neuronal activity, but also to test causality and identify potential new therapeutic approaches. We first discuss the benefits and caveats to using optogenetic approaches and recent advances in optogenetics related tools. We then turn to the use of optogenetics, including on-demand optogenetics in the study of epilepsies, which highlights the powerful potential of optogenetics for epilepsy research.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Subtitle of host publicationA View from the Bench
PublisherSpringer New York LLC
Pages319-336
Number of pages18
Volume813
ISBN (Print)9789401789134
DOIs
StatePublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume813
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • AAV
  • Arch
  • Channelrhodopsin
  • Halorhodopsin
  • On-demand
  • Optrode
  • Responsive
  • Seizure

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

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  • Cite this

    Krook-Magnuson, E., Ledri, M., Soltesz, I., & Kokaia, M. (2014). How might novel technologies such as optogenetics lead to better treatments in epilepsy? In Advances in Experimental Medicine and Biology: A View from the Bench (Vol. 813, pp. 319-336). (Advances in Experimental Medicine and Biology; Vol. 813). Springer New York LLC. https://doi.org/10.1007/978-94-17-8914-1_26