How does the plasma membrane participate in cellular signaling by receptors for immunoglobulin E?

Barbara Baird, Erin D. Sheets, David Holowka

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Accumulating evidence strongly supports the view that the plasma membrane participates in transmembrane signaling by IgE-receptors (IgE-FcεRI) through the formation of lipid-based domains, also known as rafts. Ongoing biochemical and biophysical experiments investigate the composition, structure, and dynamics of the corresponding membrane components and how these are related to functional coupling between FcεRI and Lyn tyrosine kinase to initiate signaling in mast cells. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)109-119
Number of pages11
JournalBiophysical Chemistry
Volume82
Issue number2-3
DOIs
StatePublished - Dec 13 1999

Bibliographical note

Funding Information:
The work described here was supported by National Institutes of Health grants AI09838 (E.D.S.), AI22449 and AI18306.

Keywords

  • IgE receptor
  • Lipid rafts
  • Lipid-lipid interactions
  • Lipid-protein interactions
  • Membrane domains
  • Signal transduction

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