How does the estrogen receptor work?

Jennifer M. Gross, Douglas Yee

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


In breast cancer, interruption of estrogen receptor (ER)-α function is an effective therapeutic strategy. Despite the clinical benefit of interruption of ER-α function, the precise biological action of ER-α in breast tumors is not completely understood. Results of a recent study show that ER-α promotes growth of breast cancer cells by targeting expression of signaling components of the insulin-like growth factor system. Intriguingly, the authors of this study raise the possibility that unliganded ER-α itself may affect gene expression and breast cancer biology, and they suggest a potential mechanism for ER-α to stimulate proliferation in breast cancer.

Original languageEnglish (US)
Pages (from-to)62-64
Number of pages3
JournalBreast Cancer Research
Issue number2
StatePublished - 2002


  • Breast cancer
  • Estrogen receptor
  • Insulin-like growth factors


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