How does a protein search for the specific site on DNA: The role of disorder.

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31 Scopus citations

Abstract

Proteins can locate their specific targets on DNA up to two orders of magnitude faster than the Smoluchowski three-dimensional diffusion rate. This happens due to nonspecific adsorption of proteins to DNA and subsequent one-dimensional sliding along DNA. We call such a one-dimensional route towards the target an "antenna." We studied the role of the dispersion of nonspecific binding energies within the antenna due to a quasirandom sequence of natural DNA. A random energy profile for sliding proteins slows the searching rate for the target. We show that this slowdown is different for macroscopic and mesoscopic antennas.

Original languageEnglish (US)
Article number021903
JournalPhysical review. E, Statistical, nonlinear, and soft matter physics
Volume74
Issue number2 Pt 1
DOIs
StatePublished - Aug 2006

PubMed: MeSH publication types

  • Journal Article

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