How closely related is graft-vs-leukemia to donor/recipient disparity?

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Graft-vs-host disease (GVHD) is an unwanted complication of stem cell transplant, but the graft-vs-leukemia (GVL) effect has been shown to positively affect outcomes. GVHD and GVL have similar but not identical alloreactivity, and GVL may be affected by the source of grafts, the preparative conditioning regimen, and donor genetic elements. Human leukocyte antigen (HLA) mismatch does not appear to augment the GVL effect, and increased GVHD does not necessarily lead to decreased relapse.

Original languageEnglish (US)
Pages (from-to)525-528
Number of pages4
JournalBest Practice and Research: Clinical Haematology
Volume23
Issue number4
DOIs
StatePublished - Dec 2010

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Keywords

  • Acute leukemia
  • Conditioning regimen
  • Cord blood
  • GVHD
  • GVL
  • Graft-vs-host disease
  • Graft-vs-leukemia effect
  • HLA
  • Human leukocyte antigen
  • Mismatch
  • Unrelated donor

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