How cellular movement determines the collective force generated by the Dictyostelium discoideum slug

John C. Dallon, Hans G. Othmer

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

How the collective motion of cells in a biological tissue originates in the behavior of a collection of individuals, each of which responds to the chemical and mechanical signals it receives from neighbors, is still poorly understood. Here we study this question for a particular system, the slug stage of the cellular slime mold Dictyostelium discoideum (Dd). We investigate how cells in the interior of a migrating slug can effectively transmit stress to the substrate and thereby contribute to the overall motive force. Theoretical analysis suggests necessary conditions on the behavior of individual cells, and computational results shed light on experimental results concerning the total force exerted by a migrating slug. The model predicts that only cells in contact with the substrate contribute to the translational motion of the slug. Since the model is not based specifically on the mechanical properties of Dd cells, the results suggest that this behavior will be found in many developing systems.

Original languageEnglish (US)
Pages (from-to)203-222
Number of pages20
JournalJournal of Theoretical Biology
Volume231
Issue number2
DOIs
StatePublished - Nov 21 2004

Bibliographical note

Funding Information:
Research supported in part by NIH grant GM 29123, NSF grant DMS 9805494 and NSF grant DMS 0317372, the Max Planck Institute, Leipzig, and the Alexander von Humboldt Foundation.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Cell movement
  • Cell-based model
  • Dictyostelium discoideum
  • Motive force

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