Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review)

Caixia Zhu, Qing Zhu, Chong Wang, Liming Zhang, Fang Wei, Qiliang Cai

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations

Abstract

Hypoxia-inducible factor (HIF)-1 is a central regulator in the adaptation process of cell response to hypoxia (low oxygen). Emerging evidence has demonstrated that HIF-1 plays an important role in the development and progression of many types of human diseases, including pathogen-associated cancers. In the present review, we summarize the recent understandings of how human pathogenic agents including viruses, bacteria and parasites deregulate cellular HIF-1 signaling pathway in their associated cancer cells, and highlight the common molecular mechanisms of HIF-1 signaling activated by these pathogenic infection, which could act as potential diagnostic markers and new therapeutic strategies against human infectious cancers.

Original languageEnglish (US)
Pages (from-to)1269-1276
Number of pages8
JournalInternational Journal of Oncology
Volume49
Issue number4
DOIs
StatePublished - Oct 2016
Externally publishedYes

Keywords

  • HIF-1 signaling
  • Hypoxia
  • Infectious cancer

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