Host immune consequences of asymptomatic Trichomonas vaginalis infection in pregnancy

Hyagriv N. Simhan, Brenna L. Anderson, Marijane A. Krohn, R. Phillips Heine, Begoña Martinez de Tejada, Daniel V. Landers, Sharon L. Hillier

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Objective: The purpose of this study was to define the impact of asymptomatic trichomoniasis on lower genital tract neutrophil activation in pregnancy. Study design: In this nested cohort study, pelvic examination was performed on 65 asymptomatic pregnant women between 7 and 22 weeks' with vaginal pH > 4.4. Concentrations of cervical interleukin-8 and α-defensin were determined using enzyme-linked immunosorbent assay (ELISA). Trichomonas vaginalis was detected by culture. Results: Median concentrations of vaginal fluid neutrophil defensins and cervical interleukin-8 were significantly greater among women with asymptomatic trichomoniasis (median defensins 18,622 ng/mL, median IL-8 9244 pg/mL) than their uninfected counterparts (median defensins 5144 ng/mL, median IL-8 2044 pg/mL) (P < .001). All women with asymptomatic trichomoniasis had detectable defensin and interleukin-8 concentrations. Conclusion: Asymptomatic trichomoniasis in pregnancy is accompanied by a state of neutrophil activation.

Original languageEnglish (US)
Pages (from-to)59.e1-59.e5
JournalAmerican journal of obstetrics and gynecology
Issue number1
StatePublished - Jan 2007


  • Trichomonas vaginalis
  • defensins
  • interleukin-8
  • neutrophils
  • pregnancy


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