Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

B. K. Tye; P. Sinha; R. Surosky; S. Gibson; G. Maine; S. Eisenberg

doi:10.1007/978-1-4684-5251-8_38

Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

B. K. Tye, P. Sinha, R. Surosky, S. Gibson, G. Maine, S. Eisenberg

Plant and Microbial Biology

Research output: Contribution to journal › Article › peer-review

Abstract

In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.

Original language	English (US)
Pages (from-to)	499-510
Number of pages	12
Journal	Basic life sciences
Volume	40
DOIs	https://doi.org/10.1007/978-1-4684-5251-8_38
State	Published - 1986

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title = "Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.",

abstract = "In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.",

author = "Tye, {B. K.} and P. Sinha and R. Surosky and S. Gibson and G. Maine and S. Eisenberg",

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AU - Tye, B. K.

AU - Sinha, P.

AU - Surosky, R.

AU - Gibson, S.

AU - Maine, G.

AU - Eisenberg, S.

PY - 1986

Y1 - 1986

N2 - In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.

AB - In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.

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Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

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