Host factors and consequence of chemotherapy in pediatric cancer patients

L'Aurelle A. Johnson, Julie A. Ross

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The 5-year survival rates for childhood ALL are approaching 80%, but therapy-related toxicities are common. One of the challenges in this population is determining the most efficacious therapeutic regimens for these individuals. Factors such as drug metabolism, genetics, and concomitant disease affect drug efficacy and may be important in determining therapeutic outcomes in these patients. This review will focus on these factors in the treatment of childhood ALL.

Original languageEnglish (US)
Pages (from-to)320-326
Number of pages7
JournalPediatric Blood and Cancer
Issue number3
StatePublished - Sep 2008


  • ALL
  • Pediatric oncology
  • Pharmacology


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