Host defense in oral and airway epithelia: Chromosome 20 contributes a new protein family

Colin D. Bingle, Sven U. Gorr

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

The innate immune response is of pivotal importance in defending the mucosal barriers of the body against pathogenic attack. The list of proteins that contribute to this defense mechanism is constantly being updated. In this review we introduce a novel family of secreted proteins, palate, lung, and nasal epithelium clones (PLUNCs), that are expressed in the mouth, nose and upper airways of humans, mice, rats and cows. In humans, PLUNC genes are located in a compact cluster on chromosome 20, with similar loci being found in synteneic locations in other species. The protein products of this gene cluster are predicted to be structural homologues of the human lipopolysaccharide binding proteins, lipopolysaccharide binding-protein (LBP) and bacterial permeability-increasing protein (BPI), which are known mediators of host defense against Gram-negative bacteria. On the basis of these observations we outline why we believe PLUNC proteins mediate host defense functions in the oral, nasal and respiratory epithelia.

Original languageEnglish (US)
Pages (from-to)2144-2152
Number of pages9
JournalInternational Journal of Biochemistry and Cell Biology
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2004

Keywords

  • Airway
  • Bacterial permeability-increasing protein
  • Epithelia
  • Host defence
  • Innate immunity
  • Lipopolysaccharide binding-protein
  • Oral
  • PLUNC
  • Parotid secretory protein

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