Host and microbiome genome-wide association studies: Current state and challenges

Denis Awany, Imane Allali, Shareefa Dalvie, Sian Hemmings, Kilaza S. Mwaikono, Nicholas E. Thomford, Andres Gomez, Nicola Mulder, Emile R. Chimusa

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations

Abstract

The involvement of the microbiome in health and disease is well established. Microbiome genome-wide association studies (mGWAS) are used to elucidate the interaction of host genetic variation with the microbiome. The emergence of this relatively new field has been facilitated by the advent of next generation sequencing technologies that enable the investigation of the complex interaction between host genetics and microbial communities. In this paper, we review recent studies investigating host–microbiome interactions using mGWAS. Additionally, we highlight the marked disparity in the sampling population of mGWAS carried out to date and draw attention to the critical need for inclusion of diverse populations.

Original languageEnglish (US)
Article number637
JournalFrontiers in Genetics
Volume10
Issue numberJAN
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
The authors would like to thank DAAD, the German Academic Exchange Programme, for the financial support under Reference number 91653117. Some of the authors are funded in part by the National Institutes of Health Common Fund under grant number U41HG006941, the H3ABioNet Project grant number U24HG006941, SADaCC grant number 1U01HG007459-01, and Wellcome Trust/AESA grant H3A/18/001. We are grateful to Oyekanm Nashiru and Hassan Ghazal for helpful discussions.

Funding Information:
The authors would like to thank DAAD, the German Academic Exchange Programme, for the financial support under Reference number 91653117. Some of the authors are funded in part by the National Institutes of Health Common Fund under grant number U41HG006941, the H3ABioNet Project grant number U24HG006941, SADaCC grant number 1U01HG007459-01, and Wellcome Trust/AESA grant H3A/18/001.

Publisher Copyright:
© 2007 - 2019 Frontiers Media S.A. All Rights Reserved.

Keywords

  • Genome-wide association study
  • Host-genetic
  • Host–microbiome interaction
  • Microbiome
  • Microbiome-GWAS

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