Host and Graft Factors Impacting Infection Risk in Hematopoietic Cell Transplantation

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Infection contributes significantly to morbidity and mortality in hematopoietic cell transplantation. A complex interplay of host, graft, and technical factors contributes to infectious risk in the recipient. Host factors such as age, underlying disease, and comorbidities; central venous access; and the preparative regimen contribute to mucosal disruption, organ dysfunction, and immunodeficiency before hematopoietic cell transplantation. Graft factors, including donor histocompatibility, cell source, and graft components, along with immunosuppression and graft-versus-host disease, contribute to the speed of immune reconstitution. Evaluation of these factors, plus previous and posttransplant exposure to pathogens, is necessary to best assess an individual recipient's infection risk.

Original languageEnglish (US)
Pages (from-to)311-329
Number of pages19
JournalInfectious disease clinics of North America
Volume33
Issue number2
DOIs
StatePublished - Jun 2019

Keywords

  • Hematopoietic cell transplantation
  • Immune reconstitution
  • Infection risk factors
  • Nonrelapse mortality
  • Transplant infectious disease
  • Transplant-related mortality

PubMed: MeSH publication types

  • Journal Article
  • Review

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