Hospitalization increases the risk of acute arthritic flares in gout: A population-based study over 2 decades

Nour Zleik; Mohanad M. Elfishawi; Zoran Kvrgic; Clement J. Michet; Cynthia S. Crowson; Eric L. Matteson; Tim Bongartz

doi:10.3899/jrheum.171320

Hospitalization increases the risk of acute arthritic flares in gout: A population-based study over 2 decades

Nour Zleik, Mohanad M. Elfishawi, Zoran Kvrgic, Clement J. Michet, Cynthia S. Crowson, Eric L. Matteson, Tim Bongartz

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Objective: To assess in-hospital gout flares in patients with gout. Methods: Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010. Results: There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1.19, 95% CI 0.98-1.45]. The gout flare rate increased significantly during hospitalization (RR 10.2, 95% CI 6.8-14.5). In-hospital gout flare increased the average hospital stay by 1.8 days (p < 0.001). Conclusion. Hospitalization increased the risk of gout flares 10-fold. In-hospital gout flares were associated with longer hospitalization.

Original language	English (US)
Pages (from-to)	1188-1191
Number of pages	4
Journal	Journal of Rheumatology
Volume	45
Issue number	8
DOIs	https://doi.org/10.3899/jrheum.171320
State	Published - Aug 1 2018
Externally published	Yes

Bibliographical note

Funding Information:
From the Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA. This work was made possible using the resources of the Rochester Epidemiology Project, which is supported by the US National Institute on Aging of the National Institutes of Health (NIH) under award number R01AG034676 and CTSA grant number UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.

Publisher Copyright:
Copyright © 2018. All rights reserved.

Keywords

Gout
Healthcare Use
Hospitalization
Hyperuricemia

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10.3899/jrheum.171320

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title = "Hospitalization increases the risk of acute arthritic flares in gout: A population-based study over 2 decades",

abstract = "Objective: To assess in-hospital gout flares in patients with gout. Methods: Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010. Results: There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1.19, 95% CI 0.98-1.45]. The gout flare rate increased significantly during hospitalization (RR 10.2, 95% CI 6.8-14.5). In-hospital gout flare increased the average hospital stay by 1.8 days (p < 0.001). Conclusion. Hospitalization increased the risk of gout flares 10-fold. In-hospital gout flares were associated with longer hospitalization.",

keywords = "Gout, Healthcare Use, Hospitalization, Hyperuricemia",

author = "Nour Zleik and Elfishawi, {Mohanad M.} and Zoran Kvrgic and Michet, {Clement J.} and Crowson, {Cynthia S.} and Matteson, {Eric L.} and Tim Bongartz",

note = "Funding Information: From the Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA. This work was made possible using the resources of the Rochester Epidemiology Project, which is supported by the US National Institute on Aging of the National Institutes of Health (NIH) under award number R01AG034676 and CTSA grant number UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: Copyright {\textcopyright} 2018. All rights reserved.",

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doi = "10.3899/jrheum.171320",

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AU - Kvrgic, Zoran

AU - Michet, Clement J.

AU - Crowson, Cynthia S.

AU - Matteson, Eric L.

AU - Bongartz, Tim

N1 - Funding Information: From the Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA. This work was made possible using the resources of the Rochester Epidemiology Project, which is supported by the US National Institute on Aging of the National Institutes of Health (NIH) under award number R01AG034676 and CTSA grant number UL1 TR000135 from the National Center for Advancing Translational Sciences, a component of the NIH. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: Copyright © 2018. All rights reserved.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Objective: To assess in-hospital gout flares in patients with gout. Methods: Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010. Results: There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1.19, 95% CI 0.98-1.45]. The gout flare rate increased significantly during hospitalization (RR 10.2, 95% CI 6.8-14.5). In-hospital gout flare increased the average hospital stay by 1.8 days (p < 0.001). Conclusion. Hospitalization increased the risk of gout flares 10-fold. In-hospital gout flares were associated with longer hospitalization.

AB - Objective: To assess in-hospital gout flares in patients with gout. Methods: Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010. Results: There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1.19, 95% CI 0.98-1.45]. The gout flare rate increased significantly during hospitalization (RR 10.2, 95% CI 6.8-14.5). In-hospital gout flare increased the average hospital stay by 1.8 days (p < 0.001). Conclusion. Hospitalization increased the risk of gout flares 10-fold. In-hospital gout flares were associated with longer hospitalization.

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Hospitalization increases the risk of acute arthritic flares in gout: A population-based study over 2 decades

Abstract

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