Hormone therapy and skeletal muscle strength

A meta-analysis

Sarah M. Greising, Kristen A. Baltgalvis, Dawn A. Lowe, Gordon L. Warren

Research output: Contribution to journalReview article

91 Citations (Scopus)

Abstract

Background. Our objective was to perform a systematic review and meta-analysis of the research literature that compared muscle strength in postmenopausal women who were and were not on estrogen-based hormone therapy (HT). Methods. Twenty-three relevant studies were found. Effect sizes (ESs) were calculated as the standardized mean difference, and meta-analyses were completed using a random effects model. Results. HT was found to result in a small beneficial effect on muscle strength in postmenopausal women (overall ES = 0.23; p =.003) that equated to an ∼5% greater strength for women on HT. Among the 23 studies, various muscle groups were assessed for strength, and those that benefitted the most were the thumb adductors (ES = 1.14; p < .001). Ten studies that compared muscle strength in rodents that were and were not estradiol deficient were also analyzed. The ES for absolute strength was moderate but not statistically significant (ES = 0.44; p =.12), whereas estradiol had a large effect on strength normalized to muscle size (ES = 0.66; p =.03). Conclusion. Overall, estrogen-based treatments were found to beneficially affect strength.

Original languageEnglish (US)
Pages (from-to)1071-1081
Number of pages11
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number10
DOIs
StatePublished - Oct 1 2009

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Muscle Strength
Meta-Analysis
Skeletal Muscle
Hormones
Estradiol
Estrogens
Muscles
Thumb
Therapeutics
Rodentia
Research

Keywords

  • Estradiol
  • Hormone replacement therapy
  • Postmenopausal

Cite this

Hormone therapy and skeletal muscle strength : A meta-analysis. / Greising, Sarah M.; Baltgalvis, Kristen A.; Lowe, Dawn A.; Warren, Gordon L.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 64, No. 10, 01.10.2009, p. 1071-1081.

Research output: Contribution to journalReview article

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